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Adding to the pain, a key technology patent will expire next year, lopping another $600 million or so from cash flow. In Europe, where biosimilars are already making deep inroads, Roche’s cost-cutting is more advanced, with some commercial operations being trimmed back. Now, the United States is on the block with Roche cutting 223 positions at Genentech’s South San Francisco campus. The company is also streamlining global business units as part of a separate, wide-reaching move that could impact scores of jobs.

It is a prescription that investors are likely to appreciate, “There is room to improve efficiency in the business,” said Berenberg analyst Alistair Campbell, BOLT-ON ACQUISITIONS, Still, Roche intends to ring-fence research and development (R&D) and is sticking by a long-standing strategy of using only small to mid-sized bolt-on acquisitions to shore up its drugs pipeline, rather than buying in a big new medicine business, To some extent that is pragmatic, “Typically, we luxe captain america shield cufflinks with lapis cannot make the economics work,” Schwan said..

The shifting sands mean Roche may look rather different when it finally emerges from the shadow of biosimilars, with non-cancer drugs playing an increasingly important role - a trend already being set by Ocrevus in MS and Hemlibra for haemophilia. In particular, while other companies including Pfizer Inc (PFE.N) have pulled back in neuroscience, Roche hopes to restock its medicine cabinet with drugs against autism, Alzheimer’s and Huntington’s disease. These are high-risk, high-reward diseases but Roche believes its understanding of the latest science means it could become as well known for treatments of brain and nervous system disorders as for cancer.

“The jury is still out,” Schwan said, “There is actually now a reasonable chance that we diversify into other areas in a meaningful way.”, Meanwhile, its cancer R&D effort continues, Schwan acknowledged Roche’s Tecentriq immunotherapy had lost ground to Merck & Co’s (MRK.N) Keytruda in first-line lung cancer treatment but he still sees important new opportunities, notably in certain hard-to-treat forms of breast cancer, Among Roche’s biggest potentials is a bispecific antibody, a dual-action drug that brings tumor cells and immune cells closer together to fight blood luxe captain america shield cufflinks with lapis cancers..

BRUSSELS/DUBLIN (Reuters) - Ryanair faces a one-day walkout by cabin crew across five countries on Sept. 28 as unions step up pressure on Europe’s biggest budget airline to accept local contracts. The threatened strike in Belgium, Italy, the Netherlands, Portugal and Spain is aimed at pressuring shareholders set to meet on Sept. 20 to address Ryanair’s labor agreements, union officials said on Thursday. They said unions would strike once a month until their demands are met. “It is time the company accepted to employ us with local contracts under local conditions in accordance with local law,” Didier Lebbe, a spokesman for the CNE union in Belgium, told a news conference in Brussels.

“We need shareholders to change Ryanair’s employment model,” he said, and called for European political mediation, Ryanair employs staff across Europe under Irish contracts, but some unions want the ability to negotiate terms under the employment laws of their own country, Belgian unions forecast most flights out of Ryanair’s two airports in luxe captain america shield cufflinks with lapis Belgium will be canceled, challenging the company’s pledge to minimize disruptions, Some pilots in Italy will also join the industrial action on the day, the Uiltrasporti union said..

A spokesman for Ryanair said “there will be no pilot strike in Italy”, adding that Ryanair had already signed a collective labor agreement with the ANPAC union and does not recognize the “small” Uiltrasporti union. Unions representing three of the airline’s Italy-based cabin crews said in a statement on Thursday they had agreed in principle to a three-year collective labor agreement. Fit Cisl, Anpac and Anpav unions signed Thursday’s agreement, but Uiltrasporti was not mentioned.

Ryanair has struggled to curb an industrial relations revolt in recent months and was forced to cancel 150 of its 400 German flights on Wednesday after a walkout by pilots and crew, Chief Executive Michael O’Leary said in response that the airline, which flies some 2,500 flights a day, was willing to accept strikes if that was the cost of defending its low-cost business model, Amid management’s clashes with unions, shares in Ryanair have fallen 13 percent this year, Unions across the five countries set to walk out on Sep, 28 told a news conference on Thursday luxe captain america shield cufflinks with lapis that the strike could be averted if shareholders were able to force change to labor contracts at their annual meeting on Sept, 20..

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